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Methanobrevibacter - What we know about the most abundant archaea in the human gut
Here at Biomesight, our primary focus is on gut bacteria as these comprise most of the microbiome. Most notably are the phyla Bacteroides and Firmicutes, which make up almost all microorganisms in the microbiome. This can be seen in my sample below. However, the gut is not only colonised by bacteria but also the other domains of life, Archaea and Eukarya, both of which play no small part in gut health. The gut is much more prevalent with Archaea than Eukarya, with the majority of the Archaea found in the gut belonging to the genus Methanobrevibacter. The amount of Archaea found in the gut widely varies between people, with studies finding ranges between 0.1 to 10.24 ± 4.58% coverage of the microbiome.
But what are Methanobrevibacter?
This genus of Archaea are methanogens, meaning that the microbes belonging to this genus produce methane. The most prevalent species from this genus is M. smithii, overshadowing the other most prevalent species, M. stadtmanae. This is because M. smithii is more well suited to the environment of the gut microbiome. M. smithii converts the readily available hydrogen gas, carbon dioxide, and formate into methane. This contrasts with M. stadtmanae, which is limited to using hydrogen gas, acetate, and methanol to make methane. These methanogens need to do this since these reactions sustain the production of energy for themselves via anaerobic respiration. As M. smithii has a much greater presence in the microbiome, this will be the main focus of this article.
M. smithii is in much higher numbers than M. stadtmanae because bacterial fermentation causes the production of SCFAs, other organic acids, alcohols, and gases such as hydrogen. Methanogens prevent the buildup of these gases and other reaction end products so the other microorganisms can continue with fermentation unimpeded. This is important because host absorption of SCFAs provide up to 10% of daily caloric intake, and the accumulation of gases such as hydrogen would decrease the efficiency of microbial fermentation and, thus, the yield of nutrients.
What does Methanobrevibacter do?
So, looking at the dataset from the samples in Biomesight, the median and average relative abundance for Methanobrevibacter are 0.036% and 0.146%, respectively. This seems to imply that many of us are varying from the optimum range, which has been established as a relative abundance between 0 to 0.01% Methanobrevibacter, derived from the teachings of Dr Jason Hawrelak from Probiotic Advisor. But what does having different amounts of Methanobrevibacter do? To date, there have been many studies on Methanobrevibacter, but despite this breadth of knowledge, clear conclusions have yet to be found. While many of the studies published imply that having lower quantities is beneficial, other studies claim the opposite. While the mechanisms are unclear, it has been reported that having higher quantities of M. smithii is detrimental, so logically, lower quantities would be beneficial since it helps combat the diseases associated with M. smithii:
The relative abundance of Methanobrevibacter in the gut is highly correlated with the degree of flatulence. Paradoxically, less Methanobrevibacter results in more hydrogen gas being present, which also contributes to flatulence. This increased flatulence caused by hydrogen is similarly seen in lactose intolerance and small intestinal bacterial overgrowth.
Positive correlation between breath methane and M. smithii in C-IBS patients
Methanobrevibacter presence in the gut was found to be increased in patients with multiple sclerosis 
More specifically, as the number of M. smithii increased, inflammatory responses increased, causing damage associated with multiple sclerosis
While not directly tied to the gut, it can also affect other parts of the body
M. smithii found in muscle abscesses
M. smithii found in the lungs of patients with severe pneumonia
M. smithii found together with M. oralis in the sinuses of patients with refractory sinusitis
Although UTIs are typically associated with bacteria, M. smithii has been found co-cultured with bacteria in urine samples from patients with UTIs
M. smithii was reported to be found in the vagina only in patients suffering from vaginosis and was absent in healthy individuals
It has been suggested that M. smithii is involved in mixed infections by promoting the growth of the pathogenic bacteria through mutually beneficial interactions
While unclear exactly how, it is thought that this is because methanogens control the production of essential substances used by these bacteria in diseases such as tonsillar phlegmon.
Vouchers to save at Biomesight
Looking for promotional codes and vouchers to shop and save at Biomesight? Check out our website for the latest coupon codes! We update the available list on a daily basis to ensure that you get to save when shopping online. To get the best and latest promotional codes, browse to the top of this page.
We are dedicated to helping our loyal visitors get discounts from as many online shops in the UK as possible. We have listed over 20,000 online shops based in the UK on our website each with a wide range of vouchers and coupon codes.
You will notice that there are vouchers for specific products and there are those for an assortment of products. Each of these vouchers can be used in the UK. We also offer promotional codes from brands and stores in China, Brazil, and Europe. This way, our loyal visitors will save when shopping internationally.
To find voucher codes on our website, we have selected the best voucher codes for Biomesight and placed them at the top of this page. As a result, we have saved time for our loyal visitors. So, if you are shopping at Biomesight, use coupon codes from our website. That way, you will save and enjoy your shopping experience.
What is a Biomesight voucher code?
This is a unique code generated by a computer algorithm designed to offer you discounts on your next order. Also referred to as a promotional code, discount code or promo code, online stores from around the world use the alphanumeric code to offer discounts to their customers.
How can I use Biomesight discount code?
Our voucher codes can be used in two ways. In method one, click 'SHOW CODE', copy and paste it into your shopping cart. Method two is where you click on 'VIEW OFFER' and you should be directed to the webshop. Here, the discount will be applied immediately.
How to locate voucher codes at 1001vouchercodes.co.uk?
Start by looking for your favourite store using the search function at the top of this page. If you are in search of a specific brand or product, type the name in the search bar. You can use the following function 'CATEGORIES' or 'SHOPs A-Z.'
You can also copy the voucher from Biomesight by clicking at 'VIEW OFFER' or 'SHOW OFFER.'
If the voucher code is not showing, copy it by clicking 'COPY'. If the modal is not showing, click on the big blue button with the label 'VISIT Biomesight.'
At Biomesight, you can select one or more products and add them to your shopping cart. Once you are done shopping, take a close look at the shopping cart for the space made available for your promo code. Before checkout, enter the discount code in the space provided and it should be applied automatically.
Check to ensure the voucher code is added correctly. If the voucher is not valid, then it has expired. In addition, the voucher may be valid for another product. In such a case, get another voucher code that applies for that product. Don't forget to read the terms of the discount code.
If you are successful in applying the code, share our website, voucher codes, promotional codes and offers with family and friends so that they can save too.
Are there any discount codes available for Biomesight?
At the moment there are 3 codes available and 0 offers at Biomesight.
How much benefit can I get from Biomesight?
In the past 30 days, 2 visitors saved an average of 10% at Biomesight. There are sometimes also free shipping promotions active.
How can I redeem a Biomesight discount code?
To use a Biomesight coupon, copy the code with the mouse and paste the code into the appropriate field during check out. Please note that discount coupons sometimes do not work with all orders. Sometimes you can also redeem the coupon at the physical store.
How many offers does Biomesight have on average?
There are 3 codes available today and 0 offers at Biomesight. On average, Biomesight 3 0 has coupons and/or promotions online
Are the discounts valid for everything on Biomesight?
You can save money at Biomesight by using one of the current Biomesight coupons from 1001vouchercodes.co.uk. At the moment you can save a maximum of 10%.
Until when are the discounts valid on Biomesight?
Each promotion code of Biomesight has an expiration date, the code can only be redeemed before this date. Some Biomesight offers do not have an expiration date, then the promo code is valid until Biomesight runs out of stock of this item.
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