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Voucher codes Nylos

Nylos Promo Codes ➡️ ( Nylos Discount Codes) March 2024 UK

Nylos Voucher Codes UK ✂ Up to discount in March 2024 ✅ 1 offers and Nylos Discount Code ⭐ Already 0 times used

Best Nylos Promo Code · Nylos Review and Ratings

Your gut works like a forest- The gut microbiome is composed of different types of bacteria, similar to a forest that inhabits different animals. When one species takes overhand in an uncontrolled manner the balance gets lost and the whole forest suffers. SCIENCE BASED NUTRITION- New technologies used by microbiologists means we can now analyse organisms living inside your gut – bacteria, viruses, archaea, fungi and more. This informs how you can use food to optimise towards holistic well-being and ultimately illness prevention.

ANALYSIS LIKE NEVER BEFORE- The Nylos lab partner in Europe is ISO 9001 certified and guarantees highest quality standards. Nylos uses advanced gene sequencing technologies to revolutionise the analysis of microorganisms, which enables a new view of their ubiquity and diversity. Our modern techniques allow the isolation of previously uncultured human gut bacteria. NEXT-GENERATION SEQUENCING- This technology is based on NGS (Next Generation Sequencing) where the DNA of the bacteria residing in your gut can be identified, quantified and defined to recommend you the nutrients you need to boost your health and well-being. Your gut microbiome is unique BOOST IMMUNITY- Your gut microbiome is made up of trillions of bacteria, fungi and other microbes. It plays a very important role in your well-being by helping control digestion, which can benefit your immune system.

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coupon until Apr 3rd
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How the gut microbiome affects athletic performance

Studies say that the community of microorganisms that live in the gut are associated with athleticism.

A week before the 2015 Boston Marathon, Jonathan Scheiman, then a postdoctoral researcher in the lab of geneticist George Church at Harvard Medical School in Boston, Massachusetts, was racing around the city in a hire car collecting faeces. He gathered stool samples from runners planning to participate, as well as those from non-runners — mostly fellow postdocs. After the race, he revisited his donors to collect more samples. Four years later, his efforts were rewarded with a paper describing one of the first attempts to establish a causal link between the symbiotic community of microorganisms living in our guts and athletic performance.

Although the gut microbiome has been implicated in numerous aspects of health and disease, links with athleticism are much less studied. Interest is growing, however, helped by advances over the past decade that enable researchers to reveal not just which microbes the gut harbours but also what they do. Such work suggests that the enormous diversity of organisms that make up a person’s gut microbiome — each as unique as a fingerprint — might converge on a smaller number of functions, which, in turn, could suggest candidate mechanisms. And although elite athletes and their coaches might hope to be the first to benefit, a deeper understanding of the link between the gut microbiome and physical fitness might instead benefit the health of the wider population.

Of the trillions of microorganisms that live on and inside us, most are found in the gastrointestinal tract. Some are pathogens, but many are beneficial, and the overall community is essential to human health. Disruption of the microbiome is directly linked to gastrointestinal conditions, such as inflammatory bowel disease, and has been implicated in diabetes, cancer, heart disease, obesity and even mental health disorders. The clearest indication of the microbes’ importance comes from laboratory mice conditioned to carry none at all. “They’ve got metabolic issues, immune issues, neurological issues — you name it,” says Aleksandar Kostic, a microbiologist at Harvard and a senior author on Scheiman’s study. “Introduce a normal mouse microbiome to them, and many of these phenotypes are rescued,” he adds.

Work to unpick the mind-boggling complexity of the gut microbiome has been greatly aided by technical advances over the past two decades, and more affordable genetic sequencing. To investigate a community, researchers must sequence the genetic code of hundreds of organisms simultaneously, drawn from a cast of millions. To identify the microbes present in a sample — usually faecal matter in the case of the gut microbiome — researchers could simply grind it up and sequence everything. Historically, this had two big drawbacks: it was very expensive, and it was difficult for researchers to work out which genes belonged to which microbes. It has been likened to emptying many jigsaws into a box, throwing away the lids, and then trying to solve the puzzles.

To avoid this problem, researchers use a technique known as marker-gene sequencing. This involves sequencing a single gene common to every microbe — specifically, the gene the codes for the 16S rRNA of the ribosome, part of the cellular machinery that translates RNA into proteins. Some parts of the gene are identical no matter which microbe it is from, allowing researchers to easily locate it in a sample. But other regions vary from one microbe to another — differences that make it possible to distinguish which organisms are present. The technique enables researchers to rapidly characterize microbiome composition at low cost. However, because it only uses one piece of each organism, the information it provides is limited. The variations in the 16S gene typically only permit classification of the microbes to the level of genus, not species.

Now, however, many researchers are fronting up to the challenge of sequencing everything. The plummeting cost of sequencing over the past decade or so, as well as the development of databases of microbial genomes, which serve as the puzzle-box lids that enable researchers to match genes to microbes, have made this approach much more tractable. Known as shotgun sequencing, this technique provides more detailed insights than 16S rRNA gene sequencing — microbes can be distinguished beyond even their species, right down to the strain, and researchers can more easily characterize their potential functions on the basis of known genes. As sequencing costs continue to fall, the technique is coming within reach of more researchers. “Within the next few years the price is going to be more competitive with 16S,” says nutrition scientist Alex Mohr at Arizona State University in Tempe.

The make-up of the gut microbiome is influenced by many factors, including how the person was born (vaginal or caesarean delivery), the use of drugs (especially antibiotics), smoking habits, alcohol consumption, stress levels, age and — most obviously — diet. Remarkably little, however, is known about how exercise affects the microbiome, or vice versa. Although the field is in its infancy, researchers are beginning to glimpse a relationship, along with potential mechanisms.

A frequent finding is that fitness is associated with greater microbial diversity. One 2016 study that used 16S rRNA gene sequencing found that, in 39 healthy adults, cardiorespiratory fitness correlated with microbial diversity. This was the case even after factors such as diet were accounted for. Variation in cardiorespiratory fitness was better than sex, age, body mass index (BMI) and diet at predicting the degree of species diversity in participants’ guts.

The team did not find specific genera or families of microbes that were significantly associated with fitness. But they were able to use a microbial database to infer the likely functions of the microbes associated with cardiorespiratory fitness, these included microbial mobility and fatty-acid synthesis. One role of gut bacteria is to help break down complex carbohydrates by fermentation, producing short-chain fatty acids (SCFAs) such as butyrate, acetate and propionate as by-products. SCFAs are emerging as a potentially important component of the link between the microbiome and fitness. Of the most common SCFAs, “propionate and butyrate can only be produced by gut bacteria,” says Kostic. These are thought to act as energy sources in muscle, he adds. The team found that fitter participants had higher levels of butyrate in their faeces. “Butyrate is interesting because it’s one of the principal fuel components for the cells that line your gut,” Mohr says. “Increasing their health is obviously important for gastrointestinal health overall.”

A study published the following year looked at differences between the microbiomes of amateur and professional cyclists, using the more sensitive shotgun sequencing technique. The researchers didn’t find systematic differences between amateurs and professionals, but they did find that self-reported exercise duration was associated with levels of the bacterial genus Prevotella. Levels of Prevotella also correlated with certain processes in the gut, including the metabolism of carbohydrates and branched-chain amino acids.

Some press coverage of the study, however, was problematic. The possibility that boosting the level of a specific microbe in a cyclist’s gut could increase performance led to stories trumpeting the imminent arrival of ‘poop doping’. But not only was the sample used in the study too small to draw such strong conclusions, it also wasn’t random. The authors recruited friends, who probably shared many other things in common, such as geographic location, social interactions and diet, which could result in similarities in their microbiomes. “That’s a huge confounding factor,” says Jonathan Eisen, director of the Microbiome Special Research Program at the University of California, Davis, who was one of several researchers who pushed back against the media coverage.

The difficulty of untangling the contribution of diet was highlighted in a 2014 study of professional rugby players. Using 16S rRNA gene sequencing, the authors found greater diversity in gut microbiota in the players than in non-athletes matched for age, gender and BMI. However, the team also noted that there were extreme dietary differences between the two groups. This was especially true of protein intake, which also correlated with microbial diversity. “We couldn’t quite separate exercise from the accompanying dietary changes, to see which was having the greater effect,” says one of the authors, gastroenterologist Fergus Shanahan at University College Cork, Ireland.

In 2018, Shanahan and his colleagues analysed the same samples again, but this time they used shotgun sequencing. The researchers found a clearer separation between athletes and non-athletes in terms of gene function, including differences in carbohydrate metabolism, amino-acid synthesis and the production of SCFAs. The study illustrates the power of shotgun sequencing for assembling the puzzle of microbiome function. “It’s very much a product of technology development,” says Kostic. “Even though bacteria might be taxonomically very diverse, oftentimes their basic functions are quite similar.”

Scheiman’s Boston marathon study was longitudinal from the outset. Samples were collected daily, before and after the marathon, in an effort to study the acute effects of exercise on the microbiome. The researchers used 16S rRNA sequencing, and one genus in particular caught their attention. “The thing that really jumped out was a spike in Veillonella abundance immediately after the marathon,” says Kostic. “We also noticed that Veillonella was generally higher amongst the runners, relative to sedentary controls.” With just 15 runners and 10 control participants, the sample size was limited, but the team also replicated the finding in an independent cohort of elite rowers and runners using shotgun sequencing. The task then was to work out why.

Veillonella is known to metabolize lactate, a by-product of anaerobic respiration that is responsible for the aching sensation in the muscles that can follow intense exercise. When the team analysed samples from the second cohort, it found post-exercise spikes in the expression of genes that encode proteins involved in the metabolic pathway that Veillonella uses to convert lactate into propionate. “This was one of those results where a light bulb goes off, and it just makes sense,” says Kostic. Lactate is a metabolite that would be produced in abundance during a marathon, and that Veillonella can use for energy. And the propionate produced by Veillonella promotes muscle function. The presence of these bacteria might, therefore, create a feedback loop that benefits athlete and bacteria alike. “Someone exercising regularly is creating this metabolic niche for lactate-utilizing bacteria like Veillonella,” says Kostic.

The importance of microbes that produce SCFAs has been hinted at by several studies, but only ever as an association. So, with a strong theory to test, the team conducted some experiments. First, it isolated a Veillonella strain from a runner, inoculated mice with it and then measured how long the rodents could run on a treadmill. Compared with mice inoculated with a bacterium that doesn’t metabolise lactate (Lactobacillus bulgaricus), the Veillonella-supplemented mice ran for 13% longer. It is possible that the control bacterium was having a detrimental effect, rather than Veillonella having a positive one, but a final experiment showed that administering propionate directly to mice had a similar effect on performance, compared with a saline control. “This study stands out” in taking the crucial step from correlation to causation, says Mohr.

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The Nylos mission is to provide mainstream access to personalised nutrition recommendations to help the world live healthier and happier, one meal at a time.. THE BALANCED MICROBIOME- An imbalance of unhealthy and healthy microbes in the intestines may contribute to weight gain, high blood sugar, high cholesterol and other disorders. These can be prevented through better nutrition. YOUR MICROBIOME IS THE KEY- There are more bacterial cells in your body than human cells. With over 1,000 species of bacteria in the human gut microbiome, each of them plays a different role in your body as each bacteria can be optimised using food. HOLISTIC WELLNESS- Microbes can weigh as much as 1–2 kg, which is roughly the weight of your brain. Together, they function as an extra organ in your body and can play a huge role on your overall wellness.

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